Are you wondering is it effective to drill holes in your house? Absolutely. In fact, it is one of the most popular ways of defending a wooden construction from termites.
In the first case, the holes are drilled and the insecticide is poured inside to prevent further infestations and completely stop termites from appearing.
In the seconds case, you drill holes into or close to the nests, apply an active insecticide and that way you get rid of the nest immediately. Both are very effective ways of pest-control used world-wide. On the negative side, well, you have to drill holes.